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1

The relationship between the type of destructive spondyloarthropathy and its 10

Koji Maruyama, Yukihiro Matsuyama, Makoto Yanase, Yoshihito Sakai, Yoshito Katayama, Shiro Imagama, Zenya Ito, Norimitsu Wakao, Yasutsugu Yukawa, Keigo Ito, Mitsuhiro Kamiya, Tokumi Kanemura, Koji Sat

Journal:

European Spine Journal

Year:

2009

Language:

english

File:

PDF, 203 KB

english, 2009

2

Synthesis of 9-(2,3-Dideoxy-2-fluoro-β- d - t hreo -pentofuranosyl)adenine (FddA) via a Purine 3‘-Deoxynucleoside

Takamatsu, Satoshi, Maruyama, Tokumi, Katayama, Satoshi, Hirose, Naoko, Naito, Masaki, Izawa, Kunisuke

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 118 KB

english, 2001

3

Synthesis of 1-benzyl-3-(3,5-dimethylbenzyl)uracil derivatives with potential anti-HIV activity

Isono, Yohei, Sakakibara, Norikazu, Ordonez, Paula, Hamasaki, Takayuki, Baba, Masanori, Ikejiri, Masahiro, Maruyama, Tokumi

Journal:

Antiviral Chemistry & Chemotherapy

Year:

2011

Language:

english

File:

PDF, 370 KB

english, 2011

4

One-Handed Helical Screw Direction of Homopeptide Foldamer Exclusively Induced by Cyclic α-Amino Acid Side-Chain Chiral Centers

Dr. Yosuke Demizu, Prof. Mitsunobu Doi, Dr. Masaaki Kurihara, Prof. Tokumi Maruyama, Prof. Hiroshi Suemune, Prof. Masakazu Tanaka

Journal:

Chemistry - A European Journal

Year:

2012

Language:

english

File:

PDF, 1.49 MB

english, 2012

5

ChemInform Abstract: Introduction of a Benzoyl Group onto Riboside in Aqueous Solution: One-Step Synthesis of 6-Chloropurine 2′,3′-Di-O-benzoylriboside.

Shigetada Kozai, Satoshi Takamatsu, Kunisuke Izawa, Tokumi Maruyama

Journal:

Year:

1999

File:

PDF, 31 KB

1999

6

ChemInform Abstract: Synthesis and Biological Activity of 9-(2,6-Difluorobenzyl)-9H-purines Bearing Chlorine.

Shigetada Kozai, Tokumi Maruyama

Journal:

Year:

1999

File:

PDF, 29 KB

1999

7

ChemInform Abstract: Synthesis of 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)adenine Bearing a Selectively Removable Protecting Group.

Tokumi Maruyama, Satoshi Takamatsu, Shigetada Kozai, Yoshiko Satoh, Kunisuke Izawa

Journal:

Year:

1999

File:

PDF, 35 KB

1999

8

ChemInform Abstract: Synthesis of 8-Substituted Analogues of 2′-Deoxy-2′-fluoroadenosine.

Tokumi Maruyama, Shigetada Kozai, Takako Manabe, Yuko Yazima, Yoshiko Satoh, Hiroshi Takaku

Journal:

Year:

2000

File:

PDF, 31 KB

2000

9

ChemInform Abstract: Reaction of 7-(2-Mesyloxy-2-phenylethyl)theophylline with Amines: Synthesis of 1,2,3,6-Tetrahydro-6-imino-2-oxo-7H-purine Derivatives.

Shigetada Kozai, Kyoko Ogimoto, Tokumi Maruyama

Journal:

Year:

2001

File:

PDF, 31 KB

2001

10

ChemInform Abstract: Improved Synthesis of 9-(2,3-Dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (FddA) Using Triethylamine Trihydrofluoride.

Satoshi Takamatsu, Tokumi Maruyama, Satoshi Katayama, Naoko Hirose, Kunisuke Izawa

Journal:

Year:

2001

File:

PDF, 33 KB

2001

11

ChemInform Abstract: Practical Synthesis of 9-(2,3-Dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (FddA) via a Purine 3′-Deoxynucleoside.

Satoshi Takamatsu, Tokumi Maruyama, Satoshi Katayama, Naoko Hirose, Masaki Naito, Kunisuke Izawa

Journal:

Year:

2001

File:

PDF, 33 KB

2001

12

ChemInform Abstract: Synthesis of N2-Alkylguanosine Using Mitsunobu Reaction as a Key Step

Tokumi Maruyama, Aya Yorikane, Shigetada Kozai

Journal:

Year:

2001

File:

PDF, 28 KB

2001

13

ChemInform Abstract: Synthesis and in vitro Antiviral Activity Evaluation of 9-(2-Azido-2,3-dideoxy-β-D-threo-pentofuranosyl)adenine Derivatives

Satoshi Takamatsu, Kunisuke Izawa, Tokumi Maruyama, Satoshi Katayama, Naoko Hirose, Erik De Clercq

Journal:

Year:

2001

File:

PDF, 28 KB

2001

14

ChemInform Abstract: A New Method for the Synthesis of N2-Alkylguanosines Using Mitsunobu Reaction as a Key Step.

Shigetada Kozai, Aya Yorikane, Tokumi Maruyama

Journal:

Year:

2002

File:

PDF, 32 KB

2002

15

ChemInform Abstract: Synthesis and Hypnotic Activities of 4-Thio Analogues of N3-Substituted Uridines.

Shigetada Kozai, Tokumi Maruyama, Toshiyuki Kimura, Ikuo Yamamoto

Journal:

Year:

2002

File:

PDF, 30 KB

2002

16

ChemInform Abstract: Method for the Synthesis of Uric Acid Derivatives.

Tokumi Maruyama, Shigetada Kozai, Fumi Sasaki

Journal:

Year:

2002

File:

PDF, 30 KB

2002

17

A New Method for the Synthesis of 2′-O-Benzyladenosine Using Mitsunobu Reaction.

Shigetada Kozai, Tomoyo Fuzikawa, Keisuke Harumoto, Tokumi Maruyama

Journal:

Year:

2003

File:

PDF, 118 KB

2003

18

New Strategy to Antiviral Agents from Peptide Nucleic Acid Derivatives.

Tetsuo Yamasaki, Mohamed Abdel-Aziz, Naotoshi Kiyota, Tokumi Maruyama, Masami Otsuka

Journal:

Year:

2003

File:

PDF, 69 KB

2003

19

An Industrial Process for Synthesizing Lodenosine (FddA)

Kunisuke Izawa, Satoshi Takamatsu, Satoshi Katayama, Naoko Hirose, Shigetaka Kozai, Tokumi Maruyama

Journal:

Year:

2004

File:

PDF, 71 KB

2004

20

Introduction of a Benzyl Group onto the 2′-OH of 6-Chloropurine 3′-O-Benzoylriboside

Shigetada Kozai, Tomoyo Fuzikawa, Keisuke Harumoto, Tokumi Maruyama

Journal:

Year:

2004

File:

PDF, 54 KB

2004

21

Development of an Industrial Process for Synthesizing Lodenosine (FddA)

Satoshi Takamatsu, Tokumi Maruyama, Kunisuke Izawa

Journal:

Year:

2006

File:

PDF, 8 KB

2006

22

ChemInform Abstract: Synthesis and Biological Activity of Fluorinated Nucleosides

Tokumi Maruyama, Masahiro Ikejiri, Kunisuke Izawa, Tomoyuki Onishi

Journal:

Year:

2010

File:

PDF, 15 KB

2010

23

ChemInform Abstract: A New Method for Synthesis of 2-Alkoxyadenosine Analogues.

Norikazu Sakakibara, Takashi Tsuruta, Masahiro Komatsu, Masatoshi Iwai, Tokumi Maruyama

Journal:

Year:

2012

File:

PDF, 45 KB

2012

24

Studies of nucleosides and nucleotides—LXXIV: Purine cyclonucleosides—34 a new method for the synthesis of 2'-substituted 2'-deoxyadenosines

Morio Ikehara, Tokumi Maruyama, Hiroko Miki

Journal:

Year:

1978

Language:

english

File:

PDF, 672 KB

english, 1978

25

5′-O-Masked 2′-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents

Masahiro Ikejiri, Takayuki Ohshima, Keizo Kato, Masaaki Toyama, Takayuki Murata, Kunitada Shimotohno, Tokumi Maruyama

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 272 KB

english, 2007

26

Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents

Masahiro Ikejiri, Masayuki Saijo, Shigeru Morikawa, Shuetsu Fukushi, Tetsuya Mizutani, Ichiro Kurane, Tokumi Maruyama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 189 KB

english, 2007

27

Synthesis and evaluation of 5′-modified 2′-deoxyadenosine analogues as anti-hepatitis C virus agents

Masahiro Ikejiri, Takayuki Ohshima, Akemi Fukushima, Kunitada Shimotohno, Tokumi Maruyama

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 257 KB

english, 2008

28

Reaction of O6-methylguanosine with nitrite in the presence of carboxylic acid: synthesis of the purin-2-yl carboxylate

Tokumi Maruyama, Nobuyasu Moriwaka, Yosuke Demizu, Masami Ohtsuka

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 117 KB

english, 2005

29

A concise synthesis of 3′-α-fluoro-2′,3′-dideoxyguanosine (FddG) via 3′-α-selective fluorination of 8,2′-thioanhydronucleoside

Takayoshi Torii, Tomoyuki Onishi, Kunisuke Izawa, Tokumi Maruyama

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 110 KB

english, 2006

30

Reaction of 7-(2-Mesyloxy-2-phenylethyl)theophylline with Amines: Synthesis of 1,2,3,6-Tetrahydro-6-imino-2-oxo-7H-purine Derivatives

Shigetada Kozai, Kyoko Ogimoto, Tokumi Maruyama

Journal:

Year:

2000

Language:

english

File:

PDF, 139 KB

english, 2000

31

Direct fluorination of 6-O-cyclouracil nucleosides.

Itsumaro Kumadaki, Masakazu Nakazawa, Yoshiro Kobayashi, Tokumi Maruyama, Mikio Honjo

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 84 KB

english, 1983

32

Synthesis of uracil-5- and adenine-8-phosphonic acids

Tokumi Maruyama, Zenei Taira, Mitsuyo Horikawa, Yoshiko Sato, Mikio Honjo

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 210 KB

english, 1983

33

Practical synthesis of 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA) via a purine 3′-deoxynucleoside

Satoshi Takamatsu, Tokumi Maruyama, Satoshi Katayama, Naoko Hirose, Masaki Naito, Kunisuke Izawa

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 75 KB

english, 2001

34

Improved synthesis of 9-(2,3-dideoxy-2-fluoro-β-d-threo-pentofuranosyl)adenine (FddA) using triethylamine trihydrofluoride

Satoshi Takamatsu, Tokumi Maruyama, Satoshi Katayama, Naoko Hirose, Kunisuke Izawa

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 78 KB

english, 2001

35

Reaction of guanosine derivatives with phosphorus trichloride in acetone

Mikio Honjo, Tokumi Maruyama, Sumiko Sato, Ryuji Marumoto

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 403 KB

english, 1981

36

Reaction of N3-benzyluracil and N-hydroxymethylphthalimide with the Mitsunobu reagent: synthesis of hydrazylmethyluracils

Shigetada Kozai, Shigeru Takaoka, Tokumi Maruyama

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 151 KB

english, 2002

37

Introduction of a benzoyl group onto riboside in aqueous solution: One-step synthesis of 6-chloropurine 2′,3′-di-O-benzoylriboside

Shigetada Kozai, Satoshi Takamatsu, Kunisuke Izawa, Tokumi Maruyama

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 209 KB

english, 1999

38

Properties of triple helix formation with oligodeoxyribonucleotides containing 8-oxo-2′-deoxyadenosine and 2′-modified nucleoside derivatives

Toshiaki Ishibashi, Hidefumi Yamakawa, Qing Wang, Satoru Tsukahara, Kazuyuki Takai, Tokumi Maruyama, Hiroshi Takaku

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 485 KB

english, 1996

39

A new method for the synthesis of 2′-substituted purine nucleosides total synthesis of an antibiotic 2′-amino-2′-deoxyguanosine

Morio Ikehara, Tokumi Maruyama, Hiroko Miki

Journal:

Tetrahedron Letters

Year:

1976

Language:

english

File:

PDF, 222 KB

english, 1976

40

SYNTHESIS of 2′-DEOXY-2′-FLUOROGUANYL-(3′,5′)-GUANOSINE

Maruyama, Tokumi, Kozai, Shigetada, Nakamura, Kazuo, Irie, Masachika

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2002

Language:

english

File:

PDF, 176 KB

english, 2002

41

ChemInform Abstract: One-Pot Synthesis of 2-Nitrooxyalkoxylated Inosine Analogues Using Cyclic Ether and Isoamyl Nitrite.

Norikazu Sakakibara, Masahiro Komatsu, Tokumi Maruyama

Journal:

Year:

2012

File:

PDF, 40 KB

2012

42

A NEW METHOD FOR THE SYNTHESIS OF N 2-ALKYLGUANOSINES USING MITSUNOBU REACTION AS A KEY STEP

Kozai, Shigetada, Yorikane, Aya, Maruyama, Tokumi

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2001

Language:

english

File:

PDF, 169 KB

english, 2001

43

ChemInform Abstract: Novel Synthesis of Carbocyclic Oxetanocin Analogues (2-Alkoxy-C.OXT-A) and Their Tube Formation Activities of Human Umbilical Vein Endothelial Cells (HUVEC).

Norikazu Sakakibara, Ikuko Tsukamoto, Takashi Tsuruta, Maki Takata, Ryoji Konishi, Tokumi Maruyama

Journal:

Year:

2012

File:

PDF, 32 KB

2012

44

Sumoylation of CoREST modulates its function as a transcriptional repressor

Ayako Muraoka, Atsuyo Maeda, Norie Nakahara, Midori Yokota, Tamotsu Nishida, Tokumi Maruyama, Takayuki Ohshima

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 277 KB

english, 2008

45

A novel nucleic acid analogue shows strong angiogenic activity

Ikuko Tsukamoto, Norikazu Sakakibara, Tokumi Maruyama, Junsuke Igarashi, Hiroaki Kosaka, Yasuo Kubota, Masaaki Tokuda, Hiromi Ashino, Kenichi Hattori, Shinji Tanaka, Mitsuhiro Kawata, Ryoji Konishi

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 789 KB

english, 2010

46

Halogenation of pyrimidine 6-O-cyclonucleosides

Maruyama, Tokumi, Kimura, Shuhei, Sato, Yoshiko, Honjo, Mikio

Journal:

Journal of Organic Chemistry

Year:

1983

Language:

english

File:

PDF, 664 KB

english, 1983

47

Novel Synthesis of Carbocyclic Oxetanocin Analogs (2-Alkoxy-C.OXT-A) and Their Tube Formation Activities of Human Umbilical Vein Endothelial Cells (HUVEC)

Maruyama, Tokumi, Sakakibara, Norikazu, Tsukamoto, Ikuko, Tsuruta, Takashi, Takata, Maki, Konishi, Ryoji

Journal:

Year:

2012

Language:

english

File:

PDF, 1.80 MB

english, 2012

48

A New Method for Synthesis of 2-Alkoxyadenosine Analogs

Maruyama, Tokumi, Sakakibara, Norikazu, Komatsu, Masahiro, Iwai, Masatoshi, Tsuruta, Takashi

Journal:

Year:

2011

Language:

english

File:

PDF, 727 KB

english, 2011

49

One-Pot Synthesis of 2-Nitrooxyalkoxylated Inosine Analogs Using Cyclic Ether and Isoamyl Nitrite

Maruyama, Tokumi, Sakakibara, Norikazu, Komatsu, Masahiro

Journal:

Year:

2011

Language:

english

File:

PDF, 735 KB

english, 2011

50

First Synthesis of [6-15N]-Cladribine Using Ribonucleoside as a Starting Material

Maruyama, Tokumi, Sakakibara, Norikazu, Kakoh, Ai

Journal:

Year:

2012

Language:

english

File:

PDF, 719 KB

english, 2012